Immunostaining of Oxidized DJ-1 in Human and Mouse Brains
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چکیده
منابع مشابه
Immunostaining of Oxidized DJ-1 in Human and Mouse Brains
DJ-1, the product of a causative gene of a familial form of Parkinson disease, undergoes preferential oxidation of Cys106 (cysteine residue at position 106) under oxidative stress. Using specific monoclonal antibodies against Cys106 oxidized DJ-1 (oxDJ-1), we examined oxDJ-1 immunoreactivity in brain sections from DJ-1 knockout and wild-type mice and in human brain sections from cases classifie...
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Parkinson's disease is a progressive, age-related, neurodegenerative disorder, and oxidative stress is an important mediator in its pathogenesis. DJ-1 is a causative gene of a familial form of Parkinson's disease, namely PARK7, and plays a significant role in antioxidative defense to protect the cells from oxidative stress. DJ-1 undergoes preferential oxidation at the cysteine residue at positi...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2014
ISSN: 0022-3069,1554-6578
DOI: 10.1097/nen.0000000000000087